主要学习经历
2003/01，英国东英吉利大学（UEA）约翰因茵尼斯中心（John Innes Centre）分子微生物学博士
1990/12，南开大学分子生物学研究所，分子生物学硕士
1988/07，南开大学生物学系，生物化学学士
科研工作经历
2021.11至今,bet体育365官网正规南强重点岗位教授
2021.07至今,美国新泽州立罗格斯（Rutgers）大学、新泽西医学院（NJMS）、微生物、生物化学与分子遗传学系兼职（adjunct）副教授
2013.07–2021.06,美国新泽州立罗格斯（Rutgers）大学、新泽西医学院（NJMS）、微生物、生物化学与分子遗传学系副教授
2012–2021.10,bet体育365官网正规双聘/讲座教授
2010-2021.06,美国新泽西公共健康研究所（PHRI）首席研究员（Principal Investigator）
2006–2013.06,美国新泽西医科与牙医大学（UMDNJ）新泽西医学院（NJMS）微生物与分子遗传学系助理教授、副教授
2003–2010：美国新泽西公共健康研究所（PHRI）副研究员（Research Associate Member）
1994–2001：美国纽约公共健康研究所（PHRI）研究科学家（Research Scientist）
1991–1993：南开大学分子生物学研究所研究实习员、助理研究员
主要研究方向
（1）菌应急应答及活性氧介导的程序性凋亡
（2）CRISPR介导的抗生素耐药逆转
（3）新抗生素及广谱增效剂
（4）肠道菌群及细菌感染的无创、实时体内成像
科研成果
1.代表性论文
1.Zhang, Z, D. Xu, J. Fang, D. Wang, J. Zeng, X. Liu, S. Hong, Y. Xue, X. Zhang*, X. Zhao* (2021). In situ live imaging of gut microbiota. mSphere 6 (5): e00545-21.
2.J. Zeng, L. Wu, Z. Liu, Y. Lv, J. Feng, W. Wang, Y. Xue, D. Wang, J. Li*, Xilin Zhao*. (2021). Gain-of-function mutations in acid stress response (evgS) protect Escherichia coli from killing by gallium nitrate, an antimicrobial candidate. Antimicrob. Agents Chemother. 65 (3): e01595-20 (https://doi.org/10.1128/AAC.01595-20).
3.Hong, Y., Q Li, Q. Gao, J. Xie, H. Huang, K. Drlica, X. Zhao* (2020). Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing. J Antimicrob Chemother 75 (3): 576-585. doi: 10.1093/jac/dkz485.
4.Y. Hong, J. Zeng, X. Wang, K. Drlica, X. Zhao* (2019). Post-stress bacterial cell death mediated by reactive oxygen species. Proc. Natl. Acad. Sci. U.S.A. 116 (20): 10064-10071.
5.G Luan, Y Hong, K Drlica, X Zhao* (2018). Suppression of reactive-oxygen-species accumulation accounts for paradoxical bacterial survival at high quinolone concentration. Antimicrobial Agents and Chemotherapy. 62 (3) pii: e01622-17. doi: 10.1128/AAC.01622-17.
6.Y Hong, L Li, G Luan, K Drlica, X Zhao* (2017). Contribution of reactive oxygen species to thymineless death in Escherichia coli. Nature microbiology 2 (12), 1667.
7.Mi H, Wang D, Xue Y, Zhang Z, Niu J, Hong Y, Drlica K, Zhao X*.(2016). Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing. Antimicrob Agents Chemother60(8):5054-8.
8.Long Q, Du Q, Fu T, Drlica K, Zhao X*, Xie J*. (2015). Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis. Antimicrobial Agents and Chemotherapy 59: 1782-5.
9.Zhao X, Hong Y, Drlica K. (2015). Moving forward with reactive oxygen species involvement in antimicrobial lethality. J. Antimicrob. Chemother. 70: 639-42.
10.Li L, Hong Y, Luan G, Mosel M, Malik M, Drlica K, Zhao X* (2014). Ribosomal elongation factor 4 promotes cell death associated with lethal stress. mBio 5 (6): e01708.
11.Zhao X*, Drlica K. (2014) Reactive oxygen species and the bacterial response to lethal stress. Curr. Opin. Microbiol. 21C: 1-6.
12.Malik M,Li L, Zhao X*, Kerns RJ, Berger JM, and Drlica K*. (2014). Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics. J. Antimicrob. Chemother. 69: 3227-35.
13.Yuan X, Liu Y, Bai C, Luo Y, Wang R, Wang R, Cai Y, Zhao X* (2014). Mycoplasma pneumoniae infection is associated with subacute cough. Eur Respir J. 43: 1178-81.
14.Dorsey-Oresto A, Lu T, Mosel M, Wang X, Salz T, Drlica K, Zhao X* (2013). YihE kinase is a central regulator of programmed cell death in bacteria. Cell Reports 3 (2): 528-537.
15.Mosel M, Li L, Drlica K, Zhao X* (2013). Superoxide-mediated protection of Escherichia coli from antimicrobials. Antimicrob Agents Chemother. 57: 5755-9.
16.Liu Y, Liu X, Qu Y, Wang X, Li L, Zhao X* (2012). Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents. Antimicrob Agents Chemother 56: 6048-50.
17.Liang B, Bai N, Cai Y, Wang R, Drlica K, Zhao X* (2011). Mutant prevention concentration- based pharmacokinetic/pharmacodynamic indices as dosing targets for suppressing the enrichment of levofloxacin-resistant subpopulations of Staphylococcus aureus. Antimicrob Agents Chemother 55: 2409-12.
18.Wu X, Wang X, Drlica K, Zhao X* (2011). A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. PLoS ONE 6 (8): e23909.
19.Wang X, Zhao X* (2009). Contribution of oxidative damage to antimicrobial lethality. Antimicrob Agents Chemother 53:1395-402.
20. Drlica K, Malik M, Kerns RJ, Zhao X (2008). Quinolone-mediated bacterial death. Antimicrob Agents Chemother 52: 385-92.
21. Cui, J., Liu, Y., Wang, R., Tong, W., Drlica, K., Zhao, X*. (2006). The mutant selection window in rabbits infected with Staphylococcus aureus. J. Infect. Dis. 194: 1601-8.
22. Liu, Y., Cui, J., Wang, R., Wang, X., Drlica, K., Zhao, X*. (2005). Selection of rifampicin- resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquistion of resistance. J. Antimicribial Chemotherapy.56: 1172-1175.
23. Zhao X, Drlica K (2002). Restricting the selection of antimicrobial-resistant mutant bacteria: measurement and potential use of the mutant selection window. J Infect Dis 185: 561-5.
24. Zhao X, Drlica K (2001). Restricting the selection of antibiotic-resistant mutants: a general strategy derived from fluoroquinolone studies. Clin Infect Dis 33: S147-56.
25. Zhao X, Xu C, Domagala J, Drlica K (1997). DNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance. Proc Natl Acad Sci USA 94: 13991-6.
26. Drlica K, Zhao X (1997). DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Revs 61: 377-92.
2.获资助课题
主持国家自然科学基金面上项目2项，参与中英抗生素耐药国际合作项目1项，
主持福建省自然科学基金面上项目1项，主持横向科研研发、合作项目3项。
