教育背景
2001/9-2007/1，中国科学院大连化学物理研究所生物技术部，硕博连读
1997/9-2001/7 中国地质大学（武汉），本科
工作经历
2019/4-至今, 厦门大学, bet体育365官网正规, 副教授
2010/7-2019/3，中国科学院城市环境研究所，城市环境和健康重点实验室，副研究员
2009/6-2010/6，加拿大卫生部，化学品安全局，访问学者
2007/4-2009/4，厦门大学, 化学化工学院，博士后
主要研究领域
1. 临床医学：利用系统流行病学和多组学的方法寻找生物标志物、生物靶点和代谢途径，深入探讨疾病的发病机制，建立早期预测和高危个体筛选模型，为个性化医疗和转化医学提供科学支持；基于标志物发现，开发体外诊断方法并实现临床应用。
2. 环境医学：基于转录组、肠道宏基因谱、表观遗传谱、蛋白质谱以及代谢谱，将暴露组与系统流行病学相结合，研究环境因素（环境暴露、营养、生活方式等）与疾病的关联及分子机制，用精准的方式预防疾病、促进健康。
3. 公共卫生应急平台建设：复杂样品（食品、生物样品、环境样品）中有害物质的高通量分析技术。
代表性成果
承担科研项目情况：
1. 国家自然科学基金面上项目，22076157，砷致肝脏糖脂代谢紊乱促发/加重妊娠期糖尿病的机理及干预研究、63万元、主持。
2. 国家自然科学基金面上项目，21677141，青春期砷暴露干扰雄性大鼠HPT轴内分泌/代谢通路的生殖毒性研究、65万元、主持。
3. 国家自然科学基金青年项目，21407143、饮水型砷暴露对幼鼠海马和皮质DNA甲基化/去甲基化过程的影响及干扰机制研究、26万元、主持。
4. 科技部国家重点研发计划、2017YFC0211602、大气污染对呼吸和心血管系统健康影响的早期识别技术、2967万元、骨干成员。
5. 厦门大学校长基金项目，20720190074、基于“暴露组-代谢组-精子质量”全关联分析的男性生殖健康研究、75万元、主持。
6. 中国科学院青年创新促进会人才项目，2015/01-2018/12、60万元、主持。
7. 中国科学院知识创新工程重要方向项目，KZCX2-EW-QN408、基于联合组学的全氟辛烷类污染物的人类肝脏细胞毒性研究、120万元、主持。
8. 厦门市科技计划项目，3502Z20112017、乳及乳制品中有机污染物的高通量筛查检测技术研究、100万元、主持。
9. 福建省自然科学基金面上项目，2018J01021，利用系统生物学方法研究大气颗粒物对肺部微生物及其与宿主分子交互作用网络的干扰效应及机理、6万元、主持。
10. 福建省自然科学基金面上项目，2013J01063、福建省典型酚类环境雌激素的膳食暴露和健康风险、6万元、主持。
11. 中国科学院城市环境研究所青年人才领域前沿项目，IUEZD201401、基于下丘脑-垂体-睾丸性腺轴的内分泌(激素)和代谢干扰效应及其机制研究、40万元、主持。
近年来发表的代表性论文：**通讯作者，#第一作者***
1. Zhong-Hua Lu#, Bin Sun#, Yi-Xin Wang*, Ya-Ru Wu, Yu-Jie Chen, Sheng-Zhi Sun, Shi-Jia Liang, Song Xu, Hao Chang, Heng-Gui Chen, Jie Zhang*, Ozone exposure associates with sperm quality indicators: Sperm telomere length as a potential mediating factor, Journal of Hazardous Materials. 2023, 459: 132292.
2. Rui Guo#, Qisheng Zhong, Jiaqi Liu, Peiming Bai, Zongpeng Wang, Jieling Kou, Peijie Chen*, Jie Zhang*, Bo Zhang*. Polarity-extended liquid chromatography-triple quadrupole mass spectrometry for simultaneous hydrophilic and hydrophobic metabolite analysis, Analytica Chimica Acta 2023, 1277: 341655.
3. Yiqin Zhang#, Chen Tang#, Yuwen Liu#, Hanxiang Jiang, Jiaosheng Lu, Zhonghua Lu, Liping Xu, Siyu Zhang, Lina Zhou, Jing Ye, Xianfa Xuan, Ting Wu, Xia Cao, Benhua Zhao, Liangquan Lin, Yuxin Wang, Jie Zhang*. Long-term ozone exposure was negatively associated with estimated glomerular filtration rate in Chinese middle-aged and elderly adults. Chemosphere 2023, 341：140040
4. Tasawar Khanam#, Shijia Liang#, Song Xu, Syed Ali Musstjab Akber Shah Eqani*, Mustafa Nawaz Shafqat, Hifza Rasheed, Nazia Bibi, Heqing Shen, Jie Zhang*, Arsenic exposure induces urinary metabolome disruption in Pakistani male population, Chemosphere 2023, 312: 137228.
5. Song Xu#, Yaru Wu, Yujie Chen, Wenqing Lu, Yi-Xin Wang⁎, Biling Gao, Jie Zhang ⁎, Environmental metal exposure, seminal plasma metabolome and semen quality: Evidence from Chinese reproductive-aged men, Science of the Total Environment 2022, 838: 155860.
6. Xiaoyan Du, Lianzhong Luo, Qingyu Huang, Jie Zhang⁎, Cortex metabolome and proteome analysis reveals chronic arsenic exposure via drinking water induces developmental neurotoxicity through hnRNP L mediated mitochondrial dysfunction in male rats, Science of the Total Environment 2022, 820: 153325.
7. Chen Tang#, Hanxiang Jiang#, Bin Zhao#, Yi Lin, Shengnan Lin, Tianmu Chen, Yanhua Su, Yiqin Zhang, Lina Zhou, Lianmeng Li, Jincheng Lin, Zhonghua Lu, Yao Wang, Zeyu Zhao, Longjian Liu, Yuxin Wang*, Jie Zhang*, Heqing Shen*, The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study, Journal of Translational Medicine 2022, 20:108.
8. Xuejingping Han#, Meiping Tian#, Pavel V. Shliaha, Jie Zhang*, Shoufang Jiang, Bingru Nan, Md Nur Alam, Ole N. Jensen*, Heqing Shen, Qingyu Huang*, Real-world particulate matters induce lung toxicity in rats fed with a high-fat diet: Evidence of histone modifications, Journal of Hazardous Materials 2021, 416: 126182.
9. Xiaoyan Du, Jie Zhang⁎, Xi Zhang, Karl-Werner Schramm, Bingru Nan, Qingyu Huang, Meiping Tian, Heqing Shen⁎, Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration, Science of the Total Environment 2021, 776: 145972.
10. Tasawar Khanam, Syed Ali Musstjab Akber Shah Eqani, Jie Zhang⁎, Heng Wang, Yongli Zhang, Jianbo Yang, Muhammad Sadiq, Hifza Rasheed, Heqing Shen⁎, Urinary profiles of selected metals and arsenic and their exposure pathway analysis in four large floodplains of Pakistan, Science of the Total Environment 2020, 737: 139586.
11. Yi-Xin Wang, Yan Wu, Heng-Gui Chen, Peng Duan, Liang Wang, He-Qing Shen, Wen-Qing Lu, Bin Sun, Qi Wang, Bo Zhang, Jorge E. Chavarro, Jie Zhang(*), An Pan(*), Seminal Plasma Metabolome in Relation to Semen Quality and Urinary Phthalate Metabolites among Chinese Adult Men, Environment International, 2019, 129: 354–363.
12. Yan Wu(#), Jie Zhang(#), Siyuan Peng, Xiaofei Wang, Lianzhong Luo, Liangpo Liu, Qingyu Huang, Meiping Tian, Xueqin Zhang(*), Heqing Shen(*), Multiple elements related to metabolic markers in the context of gestational diabetes mellitus in meconium, Environment International, 2018, 121: 1227–1234.
13. Jie Zhang(*), Liangpo Liu, Xiaofei Wang, Qingyu Huang, Meiping Tian, and Heqing Shen(*), Low-Level Environmental Phthalate Exposure Associates with Urine Metabolome Alteration in a Chinese Male Cohort, Environmental Science & Technology, 2016, 50: 5953-60.
14. Jie Zhang, Heqing Shen(*), Weipan Xu, Yankai Xia, Dana Boyd Barr, Xiaoli Mu, Xiaoxue Wang, Liangpo Liu, Qingyu Huang, and Meiping Tian, Urinary Metabolomics Revealed Arsenic Internal Dose-related Metabolic Alterations: a Proof-of-Concept Study in a Chinese Male Cohort, Environmental Science & Technology, 2014, 48(20): 12265-74.
15. Xiaoyan Du, Meiping Tian, Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Liangpo Liua, Heqing Shen(*), Cortex and hippocampus DNA epigenetic response to a long-term arsenic exposure via drinking water, Environmental Pollution, 2018, 234:590-600.
16. Xiaofei Wang, Liangpo Liu, Weibing Zhang(*), Jie Zhang(*), Xiaoyan Du, Qingyu Huang, Meiping Tian, Heqing Shen(*), Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans, Environmental Pollution, 2017, 229: 168-176.
17. Xiaofei Wang, Shoufang Jiang, Ying Liu, Xiaoyan Du, Weibing Zhang(*), Jie Zhang(*), Heqing Shen(*),Comprehensive pulmonary metabolome responses to intratracheal instillation of airborne fine particulate matter in rats, Science of the Total Environment, 2017, 592：41-50.
18. Xiaofei Wang(#), Jie Zhang(#), Weipan Xu, Qingyu Huang, Liangpo Liu, Meiping Tian, Yankai Xia, Weibing Zhang(*), Heqing Shen(*), Low-level environmental arsenic exposure correlates with unexplained male infertility risk, Science of the Total Environment, 2017, 571(15): 307~313.
19. Jie Zhang(*), Xiaoli Mu, Weipan Xu, Francis L. Martin, Ambreen Alamdar, Liangpo Liu, Meiping Tian, Qingyu Huang, Heqing Shen(*), Exposure to Arsenic via Drinking Water Induces 5-Hydroxymethylcytosine Alteration in Rat, Science of Total Environment, 2014, 497: 618-625.
20. Jie Zhang, Zhenzhen Huang, Minjian Chen, Yankai Xia, Francis L Martin, Weipan Xu, Wei Hang, Heqing Shen(*), Urinary Metabolome Identifies Signatures of Oligozoospermic Infertile Men, Fertility and Sterility, 2014, 102(1): 44-53.
21. Siyuan Peng(#), Jie Zhang(#), Liangpo Liu, Xueqing Zhang, Qingyu Huang, Ambreen Alamdar, Meiping Tian, Heqing Shen (*), Newborn Meconium and Urinary Metabolome Response to Maternal Gestational Diabetes Mellitus: A Preliminary Case-Control Study, Journal of Proteome Research, 2015, 14, 1799-1809.
22. Jie Zhang, Zhenzhen Huang, Yankai Xia, Francis L Martin, Wei Hang, Heqing Shen(*), Metabolomic Analysis Reveals a Unique Urinary Pattern in Normozoospermic Infertile Men, Journal of Proteome Research, 2014, 13(6): 3088-99.
23. Xiaoxue Wang, Xiaoli Mu, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum metabolomics reveals arsenic exposure disrupted lipid and amino acid metabolism in rat: a step forward in understanding chronic arsenic toxicity, Metallomics, 2015, 7(3): 544-552.
24. Qingyu Huang, Jie Zhang(*), Francis L Martin, Siyuan Peng, Meiping Tian, Xiaoli Mu, Heqing Shen(*), Perfluorooctanoic Acid Induces Apoptosis through the p53-Dependent Mitochondrial Pathway in Human Hepatic Cells: A Proteomic Study, Toxicology Letters, 2013, 223(2): 211-220.
25. Xiaoxue Wang, Jie Zhang(*), Qingyu Huang, Ambreen Alamdar, Meiping Tian, Liangpo Liu, Heqing Shen(*), Serum Metabolomics Analysis Reveals Oral Exposure to Benzo(a)pyrene Impaired Lipid Metabolism in Rats, Molecular Biosystems, 2015, 11: 753-759.
26. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Heqing Shen(*), Proteomic analysis of perfluorooctane sulfonate-induced apoptosis in human hepatic cells using the iTRAQ technique, Journal of Applied Toxicology, 2014, 34(12): 1342-51.
27. Qingyu Huang, Jie Zhang(*), Siyuan Peng, Meiping Tian, Jinsheng Chen, Heqing Shen(*), Effects of Water Soluble PM2.5 Extracts Exposure on Human Lung Epithelial cells (A549): a Proteomic Study, Journal of Applied Toxicology, 2014, 34(6): 675-687.
28. Siyuan Peng, Lijuan Yan, Jie Zhang(*), Zhanlin Wang, Meiping Tian, Heqing Shen(*), An Integrated Metabonomics and Transcriptomics Approach to Understanding Metabolic Pathway Disturbance Induced by Perfluorooctanoic acid, Journal of Pharmaceutical and Biomedical Analysis, 2013, 86: 56-64.
29. Jie Zhang, Lijuan Yan, Meiping Tian, Qingyu Huang, Siyuan Peng, Sijun Dong(*), Heqing Shen(*), The Metabonomics of Combined Dietary Exposure to Phthalates and Polychlorinated Biphenyls in Mice, Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 287-297.
获奖、荣誉、社会兼职等
厦门市双百人才，中国毒理学会呼吸毒理分会青年委员，厦门市食品安全专家
