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郑子峥

郑子峥 副教授

职务：病毒-宿主相互作用研究组组长，国家传染病诊断试剂与疫苗工程技术研究中心(NIDVD)，分子疫苗学与分子诊断学国家重点实验室(SKLVD)

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主要研究领域：

教育经历

  1. 2004/9–2012/6， 厦门大学， 生物化学与分子生物学， 博士

  2. 2000/9–2004/6， 厦门大学， 生物学， 学士

科研与学术工作经历

  1. 2016/8-至今，厦门大学，bet体育365官网正规，副教授

  2. 2012/7-2016/7，厦门大学，bet体育365官网正规，助理教授

  3. 2008-至今，厦门大学NIDVD，病毒-宿主相互作用研究组组长

现阶段主要研究兴趣

  1. 病毒、疫苗诱导的宿主B细胞（抗体）免疫应答研究（戊型肝炎病毒、乙型肝炎病毒、流感病毒、呼吸道合胞病毒）

  2. 病毒受体、感染机制及免疫逃逸机制研究（戊型肝炎病毒、呼吸道合胞病毒）

  3. 戊型肝炎临床新特征及肝外感染症状研究

  4. 呼吸道合胞病毒（致儿童肺炎）预防及治疗性疫苗、药物研发

  5. 肿瘤组织浸润性B细胞研究

部分代表性论文

  1. Chang Liu, Wei Cai, Xin Yin, Zimin Tang, Guiping Wen, Charuta Ambardekar, Xinlei Li, Dong Ying, Zongdi Feng*, Zizheng Zheng*, Ningshao Xia, An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2, Viruses, 2019, 11(1) (Co-Corresponding author)

  2. Xue Liu#, Chao Liu#, Zizheng Zheng#, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo,* Gang Liu,* and Ningshao Xia*. Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy. Advanced Materials, 2019, (Accepted, Co-First author)

  3. Si-Ling Wang, Birendra Prasad Gupta, Wen-Fang Ji, Zi-Min Tang, Gui-Ping Wen, Anurag Adhikari, Dong Ying, Xu Zhang, Chang Liu, Zi-Zheng Zheng*, Ning-Shao Xia. Application of Hepatitis E Virus-Related Markers on Samples from a Developing Country. Clin. Lab. 2019;65:235-241 (Corresponding author)

  4. Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M. Walker, Ningshao Xia, Zizheng Zheng*, Zongdi Feng*, Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection, Proceedings of the National Academy of Sciences of USA, 2018, 115(18): 4773-4778 (Co-Corresponding author)

  5. Guiping Wen, Changrong Chen, Xiuyu Song, Zimin Tang, Wenfang Ji, Siling Wang, Ke Zhang, Jun Zhang, Shanhai Ou*, Zizheng Zheng*, Ningshao Xia, Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors, Emerging Microbes & Infecttions, 2018, 7(1): 125 (Co-Corresponding author)

  6. Min Zhao#, Zi-Zheng Zheng#, Man Chen, Kayvon Modjarrad, Wei Zhang, Lu-Ting Zhan, Jian-Li Cao, Yong-Peng Sun, Jason S. McLellan, Barney S. Graham*, Ning-Shao Xia*, Discovery of prefusion respiratory syncytial virus F-specific monoclonal antibody that provides greater in vivo protection than the murine precursor of Palivizumab, Journal of Virology, 2017, 91(15): 1-17 (Co-First author)

  7. Tian, Daiyin#; Battles, Michael B.#; Moin, Syed M.; Chen, Man; Modjarrad, Kayvon; Kumar, Azad; Kanekiyo, Masaru; Graepel, Kevin W.; Taher, Noor M.; Hotard, Anne L.; Moore, Martin L.; Zhao, Min; Zheng, Zi-Zheng; Xia, Ning-Shao*; McLellan, Jason S.*; Graham, Barney S*. Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibodytargeting the fusion glycoprotein, Nature Communications, 2017.11.30, 8: 1~7

  8. Wen, Gui-Ping#; Tang, Zi-Min#; Wang, Si-Ling; Ji, Wen-Fang; Cai, Wei; Zhang, Xu; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*, Classification of human and zoonotic group hepatitis E virus (HEV) using antigen detection, Applied Microbiology and Biotechnology, 2017.12, 101(23-24): 8585~8594(Co-Corresponding author)

  9. Cai, Wei#; Tang, Zi-Min#; Wen, Gui-Ping; Wang, Si-Ling; Ji, Wen-Fang; Yang, Min; Ying, Dong; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A high-throughput neutralizing assay for antibodies and sera against hepatitis E virus, Scientific Reports, 2016.4.28, 6: 1~8(Co-Corresponding author)

  10. Tang, Zi-Min; Wang, Si-Ling; Ying, Dong; Wen, Gui-Ping; Cai, Wei; Zhang, Ke; Ji, Wen-Fang; Yang, Ming; Zheng, Zi-Zheng*; Xia, Ning-Shao*. The Bama miniature swine is susceptible to experimental HEV infection, Scientific Reports, 2016.8.18, 6: 1~6(Co-Corresponding author)

  11. Wen, Gui-Ping#; Tang, Zi-Min#; Yang, Fan; Zhang, Ke; Ji, Wen-Fang; Cai, Wei; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A valuable antigen detection method for diagnosis of acute hepatitis e. Journal of Clinical Microbiology, 2015.3.01, 53(3): 782~788(Co-Corresponding author)

  12. Min Zhao#, Xiao-Jing Li#, Zi-Min Tang, Fan Yang, Si-Ling Wang, Wei Cai, Ke Zhang, Ning-Shao Xia*, Zi-Zheng Zheng*, A comprehensive study of neutralizing antigenic sites on the hepatitis E virus (HEV) capsid by constructing, clustering and characterizing a tool box, Journal of Biological Chemistry, 2015, 290(32): 19910-19922 (Co-Corresponding author)

  13. Tang, Zi-Min#; Tang, Ming#; Zhao, Min; Wen, Gui-Ping; Yang, Fan; Cai, Wei; Wang, Si-Ling; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A novel linear neutralizing epitope of hepatitis E virus. Vaccine, 2015.7.9, 33(30): 3504~3511 (Co-Corresponding author)

  14. McLellan, Jason S ; Chen, Man; Leung, Sherman; Graepel, Kevin W; Du, Xiulian; Yang, Yongping; Zhou, Tongqing; Baxa, Ulrich; Yasuda, Etsuko;Beaumont, Tim; Kumar, Azad; Modjarrad, Kayvon; Zheng, Zizheng; Zhao, Min; Xia, Ningshao; Kwong, Peter D ; Graham, Barney S，Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science, 2013.5.31, 340(6136): 1113~1117

  15. McLellan, Jason S; Chen, Man; Joyce, M Gordon; Sastry, Mallika; Stewart-Jones, Guillaume B E; Yang, Yongping; Zhang, Baoshan; Chen, Lei; Srivatsan, Sanjay; Zheng, Anqi; Zhou, Tongqing; Graepel, Kevin W; Kumar, Azad; Moin, Syed; Boyington, Jeffrey C; Chuang, Gwo-Yu; Soto, Cinque; Baxa, Ulrich; Bakker, Arjen Q; Spits, Hergen; Beaumont, Tim; Zheng, Zizheng; Xia, Ningshao; Ko, Sung-Youl; Todd, John-Paul; Rao, Srinivas; Graham, Barney S ; Kwong, Peter D , Structure-based design of a fusion glycoprotein vaccine forrespiratory syncytial virus. Science, 2013.11.1, 342(6158): 592~598

授权发明专利

  1. 郑子峥，贾森·麦克莱伦，陈曼，赵敏，黄粱敏，巴尼·格雷厄姆，夏宁邵，RSV融合蛋白的表位以及识别其的抗体， 2019.01.17，澳大利亚，2014231357

  2. 郑子峥，贾森·麦克莱伦，陈曼，赵敏，黄粱敏，巴尼·格雷厄姆，夏宁邵，RSV融合蛋白的表位以及识别其的抗体， 2018.01.02，美国，US9856313B2

  3. 郑子峥，唐自闽，赵敏，李晓静，温桂平，李婧娴，张军，夏宁邵，特异结合戊型肝炎病毒3、4型的抗体及其用途， 2017.08.25，中国，ZL201310069913.4

主持或参加科研项目（部分）

 1. 国家自然科学基金面上项目，81871247，戊型肝炎病毒分泌型衣壳蛋白的结构与功能探究，2019/01-2022/12，主持

 2. 国家科技重大专项传染病重大专项（2018ZX10101001-002），试剂的预认证和海外分子流行病学研究，2018/01-2020/12，主持

 3. 国家自然科学基金青年科学基金项目，8170061359，中和抗体对不同类型HEV的保护机制，2018/01-2020/12, 在研，参加、骨干成员

 4. 福建省自然科学基金资助项目，2016J05201，戊型肝炎病毒基因型间宿主差异的分子机制研究，2016/04-2019/03，已结题，主持

 5. 国家自然科学基金青年科学基金项目，81401668，抗呼吸道合胞病毒高中和活性抗体的保护机制研究，2015/01-2017/12，已结题，主持

 6. 国家自然科学基金国际(地区)合作与交流项目，81361120408，单克隆抗体中和呼吸道合胞病毒的结构基础，2014/01-2016/12，已结题，参加、骨干成员

 7. 国家自然科学基金国际(地区)合作与交流项目，81161120419，中和呼吸道合胞病毒感染的分子结构基础，2012/01-2012/12，已结题，参加、骨干成员

获得学术奖励

  1. 求是奖杰出科技成就集体奖, 2015

  2. 创新人才推进计划重点领域创新团队-疫苗与体外诊断创新团队, 2013