Selected Publications

1. Qian CY, Liu XL, Xu Q, Wang ZP, Chen J, Li TT, Zheng QB, Yu H, Gu Y, Li SW, Xia NS. Recent Progress on the Versatility of Virus-Like Particles. Vaccines-Basel. 2020;8(1).

2. Zhou L, Yu H, Wang K, Chen T, Ma Y, Huang Y, Li J, Liu L, Li Y, Kong Z, Zheng Q, Wang Y, Gu Y, Xia N, Li S. Genome re-sequencing and reannotation of the Escherichia coli ER2566 strain and transcriptome sequencing under overexpression conditions. BMC Genomics. 2020;21(1):407.

3. Wang DN, Liu XL, Wei MX, Qian CY, Song S, Chen J, Wang ZP, Xu Q, Yang YR, He MZ, Chi X, Huang SW, Li TT, Kong ZB, Zheng QB, Yu H, Wang YB, Zhao QJ, Zhang J, Xia NS, Gu Y, Li SW. Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. Nat Commun. 2020;11(1).

4. Li TT, Zheng QB, Yu H, Wu DH, Xue WH, Xiong HL, Huang XF, Nie MF, Yue MX, Rong R, Zhang SB, Zhang YY, Wu YT, Wang SJ, Zha ZH, Chen TT, Deng TT, Wang YB, Zhang TY, Chen YX, Yuan Q, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. SARS-CoV-2 spike produced in insect cells elicits high neutralization titres in non-human primates. Emerg Microbes Infec. 2020;9(1):2076-90.

5. He MZ, Xu LF, Zheng QB, Zhu R, Yin ZC, Zha ZH, Lin Y, Yang LS, Huang Y, Ye XZ, Li SX, Hou WH, Wu YT, Han JL, Liu DX, Li ZK, Chen ZQ, Yu H, Que YQ, Wang YB, Yan XD, Zhang J, Gu Y, Zhou ZH, Cheng T, Li SW, Xia NS. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host & Microbe. 2020;27(2):249-+.

6. Zhang YL, Wang SJ, Wu YT, Hou WH, Yuan LZ, Sheng CG, Wang J, Ye JH, Zheng QB, Ma J, Xu JJ, Wei M, Li ZL, Nian S, Xiong HL, Zhang L, Shi Y, Fu BR, Cao JL, Yang CL, Li ZY, Yang T, Liu L, Yu H, Hu JD, Ge SX, Chen YX, Zhang TY, Zhang J, Cheng T, Yuan Q, Xia NS. Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors. Small Methods. 2020.

7. Wang W, Zheng QB, Pan DQ, Yu H, Fu WK, Liu J, He MZ, Zhu R, Cai YZ, Huang Y, Zha ZH, Chen ZQ, Ye XZ, Han JL, Que YQ, Wu T, Zhang J, Li SW, Zhu H, Zhou ZH, Cheng T, Xia NS. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nat Microbiol. 2020;5(12):1542-+.

8. Chen HY, Chen YZ, Deng M, John S, Gui X, Kansagra A, Chen WN, Kim J, Lewis C, Wu GJ, Xie JJ, Zhang LB, Huang R, Liu XY, Arase H, Huang Y, Yu H, Luo WX, Xia NS, Zhang NY, An ZQ, Zhang CC. Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells. J Immunother Cancer. 2020;8(2).

9. Zhang ZQ, Wei X, Lin YL, Huang F, Shao J, Qi JL, Deng TT, Li ZZ, Gao SQ, Li SY, Yu H, Zhao QJ, Le SW, Gu Y, Xia NS. HIV-1 Membrane-Proximal External Region Fused to Diphtheria Toxin Domain-A Elicits 4E10-Like Antibodies in Mice. Immunol Lett. 2019;213:30-8.

10. Wang ZT, Xu LF, Yu H, Lv P, Lei Z, Zeng Y, Liu G, Cheng T. Ferritin nanocage-based antigen delivery nanoplatforms: epitope engineering for peptide vaccine design. Biomater Sci-Uk. 2019;7(5):1794-800.

11. Li TT, Zhang ZY, Zhang ZQ, Qiao JM, Rong R, Zhang YY, Yao QB, Li ZK, Shen HL, Huang F, Xue WH, Gao SQ, Li SY, Zheng QB, Yu H, Zhang J, Gu Y, Li SW, Xia NS. Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells. Vaccine. 2019;37(11):1418-27.

12. Liu XL, Chen J, Wang ZP, Wang DN, He MZ, Qian CY, Song S, Chi X, Kong ZB, Zheng QB, Wang YB, Yu H, Zhao QJ, Zhang J, Li SW, Gu Y, Xia NS. Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection. Emerg Microbes Infec. 2019;8(1):1721-33.

13. Zheng QB, Zhu R, Xu LF, He MZ, Yan XD, Liu DX, Yin ZC, Wu YT, Li YC, Yang LS, Hou WH, Li SX, Li ZZ, Chen ZQ, Li ZH, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS, Cheng T, Li SW, Xia NS. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nat Microbiol. 2019;4(1):124-+.

14. Zheng QB, Jiang J, He MZ, Zheng ZZ, Yu H, Li TT, Xue WH, Tang ZM, Ying D, Li ZK, Song S, Liu XL, Wang KH, Zhang ZQ, Wang DN, Wang YB, Yan XD, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. Viral neutralization by antibody-imposed physical disruption. Proc Natl Acad Sci U S A. 2019;116(52):26933-40.

15. Chen TT, Wang KH, Chi X, Zhou LZ, Li JJ, Liu LQ, Zheng QB, Wang YB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. Construction of a bacterial surface display system based on outer membrane protein F. Microb Cell Fact. 2019;18.

16. Wang KH, Zhou LZ, Zhang X, Song CL, Chen TT, Li JJ, Zheng MH, Wang YB, Zheng QB, Zheng ZZ, Yu H, Wu T, Gu Y, Zhang J, Zhao QJ, Li SW, Xia NS. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A. Antiviral Res. 2019;164:154-61.

17. Shen CG, Zhang MW, Chen YZ, Zhang LM, Wang GS, Chen JY, Chen SY, Li ZZ, Wei FX, Chen J, Yang KY, Guo SX, Wang YJ, Zheng QB, Yu H, Luo WX, Zhang J, Chen HL, Chen YX, Xia NS. An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency. Theranostics. 2019;9(1):210-31.

18. Wei MX, Wang DN, Li ZH, Song S, Kong XL, Mo XB, Yang YR, He MZ, Li ZY, Huang B, Lin ZJ, Pan HR, Zheng QB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro. Emerg Microbes Infec. 2018;7.

19. Lin QS, Li TT, Chen YX, Lau SY, Wei MX, Zhang YY, Zhang ZY, Yao QB, Li JJ, Li ZH, Wang DN, Zheng QB, Yu H, Gu Y, Zhang J, Chen HL, Li SW, Xia NS. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J Virol. 2018;92(17).

20. Zhu R, Xu LF, Zheng QB, Cui YX, Li SW, He MZ, Yin ZC, Liu DX, Li SX, Li ZZ, Chen ZQ, Yu H, Que YQ, Liu C, Kong Z, Zhang JB, Baker TS, Yan XD, Zhou ZH, Cheng T, Xia NS. Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Sci Adv. 2018;4(9).

21. Xin L, Yu H, Hong QY, Bi XJ, Zhang X, Zhang ZQ, Kong ZB, Zheng QB, Gu Y, Zhao QJ, Zhang J, Li SW, Xia NS. Identification of Strategic Residues at the Interface of Antigen-Antibody Interactions by In Silico Mutagenesis. Interdiscip Sci. 2018;10(2):438-48.

22. Li ZH, Song S, He MZ, Wang DN, Shi JJ, Liu XL, Li YB, Chi X, Wei SP, Yang YR, Wang ZP, Li JJ, Qian HL, Yu H, Zheng QB, Yan XD, Zhao QJ, Zhang J, Gu Y, Li SW, Xia NS. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun. 2018;9.

23. Zheng MH, Jiang J, Zhang X, Wang N, Wang KH, Li Q, Li TT, Lin QS, Wang YB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. Characterization of capsid protein (p495) of hepatitis E virus expressed ID in Escherichia coli and assembling into particles in vitro. Vaccine. 2018;36(16):2104-11.

24. Li ZH, Wang DN, Gu Y, Song S, He MZ, Shi JJ, Liu XL, Wei SP, Li JJ, Yu H, Zheng QB, Yan XD, Baker TS, Zhang J, McLellan JS, Li SW, Xia NS. Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. Mbio. 2017;8(5).

25. Shen CG, Chen JY, Li R, Zhang MY, Wang GS, Stegalkina S, Zhang LM, Chen J, Cao JL, Bi XJ, Anderson SF, Alefantis T, Zhang MW, Cai XY, Yang KY, Zheng QB, Fang MJ, Yu H, Luo WX, Zheng ZZ, Yuan Q, Zhang J, Shih JWK, Kleanthous H, Chen HL, Chen YX, Xia NS. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Sci Transl Med. 2017;9(412).

26. Wu YT, Zhu R, Xu LF, Li YC, Li SX, Yu H, Li SW, Zhu H, Cheng T, Xia NS. A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against enterovirus 71 and varicella-zoster virus. Vaccine. 2017;35(20):2728-35.

27. Wang D, Fan F, Li ZH, Liu XL, Song S, Wei SP, He MZ, Lin YH, Li ZY, Wei MX, Yu H, Gu Y, Li SW, Xia NS. Stop codon mutagenesis for homogenous expression of human papillomavirus L1 protein in Escherichia coli. Protein Expression and Purification. 2017;133:110-20.

28. Lin YQ, Min XP, Li LL, Yu H, Ge SX, Zhang J, Xia NS. Using a Machine-Learning Approach to Predict Discontinuous Antibody-Specific B-Cell Epitopes. Curr Bioinform. 2017;12(5):406-15.

29. Zhang X, Wang KH, Lin QS, Zheng MH, Li Q, Li TT, Hong QY, Zheng QB, Yu H, Gu Y, Li SW, Xia NS. A shared N-terminal hydrophobic tail for the formation of nanoparticulates. Nanomedicine. 2016;11(17):2289-303.

30. Yang LS, Liu YJ, Li SX, Zhao H, Lin QN, Yu H, Huang XM, Zheng QB, Cheng T, Xia NS. A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice. Vaccine. 2016;34(48):5938-45.

31. Li ZH, Yan XD, Yu H, Wang DN, Song S, Li YB, He MZ, Hong QY, Zheng QB, Zhao QJ, Gu Y, Zhang J, Janssen MEW, Cardone G, Olson NH, Baker TS, Li SW, Xia NS. The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. Structure. 2016;24(6):874-85.

32. Xia L, Xian YF, Wang DN, Chen YZ, Huang XF, Bi XJ, Yu H, Fu Z, Liu XL, Li SW, An ZQ, Luo WX, Zhao QJ, Xia NS. A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5. Sci Rep. 2016;6.

33. Hou WH, Fang C, Liu JY, Yu H, Qi JL, Zhang ZQ, Yuan RX, Xiong D, Gao SQ, Yuan YA, Li SW, Gu Y, Xia NS. Molecular insights into the inhibition of HIV-1 infection using a CD4 domain-1-specific monoclonal antibody. Antiviral Res. 2015;122:101-11.

34. Hou WH, Yang LS, Li SX, Yu H, Xu LF, He DL, Chen MY, He SZ, Ye XZ, Que YG, Shih JWK, Cheng T, Xia NS. Construction and characterization of an infectious cDNA clone of Echovirus 25. Virus Res. 2015;205:41-4.

35. Xia L, Zhang J, Cui CJ, Bi XJ, Xiong JH, Yu H, An ZQ, Luo WX, Xia NS. In vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay. J Biochem. 2015;158(6):531-8.

36. Xu LF, He DL, Yang LS, Li ZQ, Ye XZ, Yu H, Zhao H, Li SX, Yuan LZ, Qian HL, Que YQ, Shih JWK, Zhu H, Li YM, Cheng T, Xia NS. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Sci Rep. 2015;5.

37. Wang DN, Li ZH, Xiao JQ, Wang JQ, Zhang L, Liu YJ, Fan F, Xin L, Wei MX, Kong ZB, Yu H, Gu Y, Zhang J, Li SW, Xia NS. Identification of Broad-Genotype HPV L2 Neutralization Site for Pan-HPV Vaccine Development by a Cross-Neutralizing Antibody. PLoS One. 2015;10(4).

38. Gui X, Li R, Zhang XH, Shen CG, Yu H, Guo XY, Kang YH, Chen JY, Chen HL, Chen YX, Xia NS. An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2. Virology. 2014;464:11-20.

39. Wei MX, Zhang X, Yu H, Tang ZM, Wang KH, Li ZY, Zheng ZZ, Li SW, Zhang J, Xia NS, Zhao QJ. Bacteria expressed hepatitis E virus capsid proteins maintain virion-like epitopes. Vaccine. 2014;32(24):2859-65.

40. Gui X, Ge PH, Wang XL, Yang KY, Yu H, Zhao QJ, Chen YX, Xia NS. Identification of a Highly Conserved and Surface Exposed B-cell Epitope on the Nucleoprotein of Influenza A Virus. J Med Virol. 2014;86(6):995-1002.

41. You M, Xin L, Yang Y, Zhang X, Chen YW, Yu H, Li SW, Zhang J, An Z, Luo WX, Xia NS. Investigation of a special neutralizing epitope of HEV E2s. Protein & Cell. 2014;5(12):950-3.

42. Xu LF, He DL, Li ZQ, Zheng J, Yang LS, Yu M, Yu H, Chen YX, Que YQ, Shih JWK, Liu G, Zhang J, Zhao QJ, Cheng T, Xia NS. Protection against Lethal Enterovirus 71 Challenge in Mice by a Recombinant Vaccine Candidate Containing a Broadly Cross-Neutralizing Epitope within the VP2 EF Loop. Theranostics. 2014;4(5):498-513.

43. Zhao QJ, Li SW, Yu H, Xia NS, Modis Y. Virus-like particle-based human vaccines: quality assessment based on structural and functional properties. Trends Biotechnol. 2013;31(11):654-63.

44. Huang CH, Yuan Q, Chen PJ, Zhang YL, Chen CR, Zheng QB, Yeh SH, Yu H, Xue Y, Chen YX, Liu PG, Ge SX, Zhang J, Xia NS. Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors. J Hepatol. 2012;57(4):720-9.

45. Yu H, Li SW, Yang CY, Wei MX, Song CL, Zheng ZZ, Gu Y, Du HL, Zhang J, Xia NS. Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78. J Mol Model. 2011;17(5):987-95.

46. Zheng QB, Xia L, Wu WL, Zheng ZH, Huo YT, Wu J, Liu YN, Yu H, Chen YX, Lau SY, Chen HL, Luo WX, Xia NS. Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses. Antimicrobial Agents and Chemotherapy. 2011;55(4):1349-57.

47. Zheng ZZ, Miao J, Zhao M, Tang M, Yeo AET, Yu H, Zhang J, Xia NS. Role of heat-shock protein 90 in hepatitis E virus capsid trafficking. J Gen Virol. 2010;91:1728-36.

48. Yu H, Yuan Q, Ge SX, Wang HY, Zhang YL, Chen QR, Zhang J, Chen PJ, Xia NS. Molecular and Phylogenetic Analyses Suggest an Additional Hepatitis B Virus Genotype I''. PLoS One. 2010;5(2).