周子健 副教授/博导
研究方向：磁共振成像、分子影像学、化学生物学、炎症免疫疾病、纳米医学、转化医学
通信地址：福建省厦门市翔安区翔安南路4221-116号厦门大学翔安校区分子影像大楼306室
电 话：0592-2880649
邮 箱：zhouz@xmu.edu.cn
个人简介：
周子健博士于2015年在厦门大学化学化工学院获得化学生物学博士学位（导师：高锦豪教授），2015-2020年在美国国立卫生研究院（NIH）从事访问和博士后研究工作（导师：Xiaoyuan (Shawn) Chen，现为新加坡国立大学终身教授）。2020年10月加入厦门大学分子影像暨转化医学研究中心。曾获得美国国立卫生研究院（NIH）研究员“卓越研究奖”（Fellows Award for Research Excellence, FARE），2019年被选为美国生物医学影像和工程研究所（NIBIB）研究员代表在NIH年会上汇报工作，入选厦门大学“南强青年拔尖人才”计划（特任研究员）、厦门市高层次留学引进人才等。
周子健博士多年来围绕磁共振分子影像中的三个关键科学问题：（1）造影剂探针的弛豫增强机制；（2）磁共振造影成像的特异性如何提高；（3）针对特定分子的生物功能成像。在分子弛豫机制、分子影像探针的构建和应用、生物活性分子的诊疗功能影像三个方面开展了具有创新地特色研究工作。迄今共发表学术论文80余篇，撰写英文专著章节1章。据Google Scholar统计论文总被引5600余次、H因子为42。以第一或通讯作者在Nature Communications等杂志发表论文20余篇，单篇最高被引800余次，多篇入选ESI高被引论文或杂志卷首论文。现担任ACS Nano、Angew Chem Int Ed、Adv Mater、Adv Sci等国际学术期刊的独立审稿人。
主要论文（*通讯作者，†共同一作）：
1. Shi, C.; Zhou, Z.*; Lin, H.*; Gao, J.* Imaging beyond Seeing: Early Prognosis of Cancer Treatment. Small Methods 2021, 6, 2001025. (Special Issue for the 100th Anniversary of Xiamen University).
2. Zhou, Z.; Deng, H.; Yang, W.; Wang, Z.; Lin, L.; Munasinghe, J.; Jacobson, O.; Liu, Y.; Tang, L.; Ni, Q.; Kang, F.; Liu, Y.; Niu, G.; Bai, R.; Qian, C.; Song, J.*; Chen, X.* Early stratification of radiotherapy response by activatable inflammation magnetic resonance imaging. Nat. Commun. 2020, 11, 3032.
3. Zhou, Z.†; Tian, R.†; Wang, Z. Y.; Yang, Z.; Liu, Y. J.; Liu, G.; Wang, R. F.; Gao, J. H.; Song, J.*; Nie, L.*; Chen, X.*, Artificial Local Magnetic Field Inhomogeneity Enhances T2 Relaxivity. Nat. Commun. 2017, 8, 15468.
4. Zhou, Z.; Chan, A.; Wang, Z.; Huang, X.; Yu, G.; Jacobson, O.; Wang, S.; Liu, Y.; Shan, L. L.; Dai, Y.; Shen, Z.; Lin, L. S.; Chen, W.; Chen, X.* Synchronous Chemoradiation Nanovesicles by X-ray Triggered Cascade of Drug Release. Angew. Chem. Int. Ed. 2018, 130, 8463-8467.
5. Zhou, Z.†; Song, J.†; Tian, R.; Yang, Z.; Yu, G.; Lin, L.; Zhang, G.; Fan, W.; Zhang, F.; Niu, G.; Nie, L.*; Chen, X.*, Activatable Singlet Oxygen Generation from Lipid Hydroperoxide Nanoparticles for Cancer Therapy. Angew. Chem. Int. Ed. 2017, 129, 6592-6596. (ESI Highly Cited Paper)
6. Zhou, Z.; Bai, R.*; Wang, Z.; Bryant, H.; Lang, L.; Merkle, H.; Munasinghe, J.; Tang, L.; Tang, W.; Tian, R.; Yu, G.; Ma, Y.; Niu, G.; Gao, J.*; Chen, X.* An Albumin-Binding T1-T2 Dual-modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging. Bioconjugate Chem. 2019, 30, 1821-1829.
7. Tang, L.; Wang, Z.; Mu, Q.; Yu, Z.*; Jacobson, O.; Li, L.; Yang, W.; Huang, C.; Kang, F.; Fan, W.; Ma, Y.; Wang, M.*; Zhou, Z.*; Chen, X.* Targeting Neutrophils for Enhanced Cancer Theranostics. Adv. Mater. 2020, 32 (33), 2002739.
8. Zhou, Z.; Yang, L.; Gao, J.*; Chen, X.* Structure–Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567. (Review) (ESI Highly Cited Paper)
9. Zhou, Z.; Song, J.; Nie, L.*; Chen, X.*, Reactive Oxygen Species Generating Systems Meeting Challenges of Photodynamic Cancer Therapy. Chem. Soc. Rev. 2016, 45, 6597-6626. (Review) (ESI Highly Cited Paper)
10. Zhou, Z.*; et al. Chen, X.* Dancing with Reactive Oxygen Species Generation and Elimination in Nanotheranostics for Disease Treatment. Adv. Drug. Deliv. Rev. 2020 (Invited Review: ADDR Special Theme Issue “Advanced Drug Delivery 2020”)
11. Song, J.; Lin, L.; Yang, Z.; Zhu, R.; Zhou, Z.*; Li, Z.*; Wang, F.; Chen, J.; Yang, H.*; Chen, X.* Self-Assembled Responsive Bilayered Vesicles with Adjustable Oxidative Stress for Enhanced Cancer Imaging and Therapy. J. Am. Chem. Soc. 2019, 141, 8158.
12. Shen, Z.; Song, J.; Yung, B; Zhou, Z.*; Wu, A.*; Chen, X.*, Emerging Strategies of CancerTherapy Based on Ferroptosis. Adv. Mater. 2018, 30, 1704007. (Review) (Featured as Frontispiece Article) (ESI Highly Cited Paper)
13. Zhou, Z.; Bai, R.; Munasinghe, J.; Shen, Z.; Nie, L.*; Chen, X.*, T1–T2 Dual–Modal Magnetic Resonance Imaging: From Molecular Basis to Contrast Agents. ACS Nano 2017, 11, 5227–5232. (Perspective)
14. Zhou, Z.; Shen, Z.*; Chen, X.* Tale of Two Magnets: An Advanced Magnetic Targeting System. ACS Nano 2020, 14, 7-11. (Perspective)
15. Tang, L.; Yang, Z.; Zhou, Z.*; Ma, Y.; Kiesewetter, D.; Wang, Z.; Fan, W.; Zhu, S.; Zhang, M.; Tian, R.; Lang, L.; Niu, G.; Zhang, X.*; Chen, X.* A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy. Theranostics. 2019, 9, 1358-1368.
16. Zhou, Z.; Hu, R.; Wang, L.; Sun C.; Fu, G.; Gao, J.*, Water Bridge Coordination on The Metal-Rich Facets of Gd2O3 Nanoplates Confers High T1 Relaxivity. Nanoscale 2016, 45, 17887-17894.
17. Zhou, Z.†; Wu, C. Q.†; Liu, H. Y.; Zhu, X. L.; Zhao, Z.; Wang, L.; Xu, Y.; Ai, H.; Gao, J. H.*, Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.
18. Zhou, Z.; Zhu, X. L.; Wu, D.; Chen Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K. Y.; Gao, J.*, Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Chem. Mater. 2015, 27, 3505-3515.
19. Zhou, Z.†; Liu, H.†; Chi, X.†; Chen, J.; Wang, L.; Sun, C.; Chen, Z.; Gao, J. H.*, A Protein-Corona-Free T1–T2 Dual-Modal Contrast Agent for Accurate Imaging of Lymphatic Tumor Metastasis. ACS Appl. Mater. Interfaces 2015, 7, 28286.
20. Zhou, Z.†; Zhao, Z.†; Zhang, H.; Wang, Z.; Chen, X. Y.; Wang, R.; Chen, Z.; Gao, J. H.*, Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.
21. Zhou, Z.; Wang, L. R.; Chi, X.; Bao, J. F.; Yang, L.; Zhao, W.; Chen, Z.; Wang, X.; Chen, X. Y.; Gao, J. H.*, Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.
22. Zhou, Z.; Huang, D. T.; Bao, J.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.*, A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.
Book Chapter
1. Zhou, Z.; Chen, X.*, Magnetic Nanomaterials for Diagnostics in Magnetic Nanomaterials-Fundamentals, Synthesis and Applications, 365-392. Editor: Yanglong Hou, John Wiley & Sons (2017)
