赵庆亮工学博士，专业生物医学工程，中国光学学会第三届生物医学光子学青年委员，研究小组紧密围绕 “生物医学光学与分子影像”医工交叉领域，聚焦“光学相干、光声成像、微循环可视化成像理论与仪器开发、多模态分子探针与跨尺度融合关键技术、光声/OCT内窥成像、人工智能与信号图像处理医学交叉领域的研究。

课题组取得了一系列研究成果：1) 建立了小动物高分辨光声成像系统（PAI）、光学相干层析成像系统（OCT）、光学相干血管造影系统（OCTA）以及多模态光声/光学相干成像系统，发展了高分辨三维对比增强分子影像技术及图像特征提取算法；2) 开发活体微循环血流检测成像系统，制备多功能型分子影像探针；3) 多模态及内窥成像系统开发、探头设计及临床转化。至今在国际知名学术期刊：Environ. Health. Persp., Adv. Sci., Opt. Lett., Opt. Express., Photoacoustics., Adv. Funct. Mater., Small., Chem. Eng. J., J. Biophotonics., Biomed.Opt. Express., J. Biomed. Opt., Chem. Commun等发表研究性论文 60 余篇，申请专利 10 余项，8项已授权，担任多个国际知名期刊审稿人 ，Applied Sciences 客座编辑，生物医学工程学会资深会员，2021年入选福建省高层次引进人才（C类）；2020年入选厦门市高层次引进人才。

主讲本科生课程：医学科研设计与论文撰写、分子影像检验技术 、仪器分析实验

主讲研究生课程：分子影像学基础

主持项目：

国家自然科学基金项目、福建省双创（联合）、引导性项目、广东省面上项目、厦门市科技计划项目、厦门大学校长基金培育项目、横向项目；国家级大创等。

研究方向：

光学相干层析、光声及多尺度成像系统研发与临床转化

多模态分子探针开发、生物光子与分子影像

图像信息处理与人工智能

光透明技术开发及其机制

招生兴趣：

1. 仪器科学、声学、光学、计算机、生物医学工程、脑科学、肿瘤学等相关专业优秀的本科生；

2. 热爱科研、责任心强、踏实进取，对研发光学成像仪器及其分子影像、生物医学相关领域应用有浓厚兴趣，有攻读博士学位意愿者；

3. 熟练掌握一种或多种编程语言，如MATLAB、LabView、C/C++、Python、Qt等；

4. 具有良好的英文写作能力。

诚挚欢迎对以上研究方向感兴趣的同学报考加盟本小组，有意者可随时发送简历或电话沟通。

论文：（#共同作者，*通讯作者，@本科生）：

1.   Fei Ye^#, Bei Zhang^#, Lige Qiu, Yunrui Zhang,... Qingliang Zhao*, Ligong Lua*, and Zhenlin Zhang*. In Vivo Real-Time RBC Migration and Microcirculation Flow Synergy Imaging-Surveyed Thrombolytic Therapy with Iron-oxide Complexes. Materials Today Bio, (Accepted) (IF 10.761).

2.   Fengqiu Hong, Xiaorui Geng, Guangzong Min, Xiang Sun, Bei Zhang, Youliang Yao, Ronghui Li, Jing Wang, Hengyu Zhao, Peng Guo, Zhen Yuan*, Xiaofei Wen*, Liming Nie*, Gang Liu, Xiaoyuan Chen, Qingliang Zhao*. Deep NIR-II optical imaging combined with minimally invasive interventional photothermal therapy for orthotopic bladder cancer.  Chem. Eng. J., 2022. 449，137846. (IF 16.744). 

3.   Qi Qiu^#, Yali Huang^#, Bei Zhang^#, Doudou Huang, Xin Chen, Zhongxiong Fan, Jinpei Lin, Wensheng Yang, Kai Wang, Ning Qu, Juan Li, Zhihong Li^@, Jingyu Huang^@, Shenrui Li^@, Jiaxing Zhang, GangLiu, Gang Rui*, Xiaoyuan Chen*, Qingliang Zhao*. Non-invasive Dual-modality Photoacoustic-ultrasonic Imaging to Detect Mammalian Embryo Abnormalities After Prenatal Exposure to Methylmercury Chloride (MMC): A Mouse Study., Environ. Health. Persp., 2022, 130 (2): 027002.(IF 11.035). (Science Selection) 新闻报道 (https://ehp.niehs.nih.gov/doi/10.1289/EHP11126).

4.   Luen Xu#, Jianxin Wang#, Jingjing Wang, Shi-Yu Lu, Qiang Yang, Chunmei Chen, Huawei Yang, Fengqiu Hong, Changjun Wu, Qingliang Zhao*, Yang Cao*, Hui Liu*, Polypyrrole-iron phosphate-glucose oxidase-based nanocomposite with cascade catalytic capacity for tumor synergistic apoptosis-ferroptosis therapy, Chem. Eng. J., 2022,427, 131671.(IF 16.744).

5.   Guangzong Min#, Fengqiu Hong#, Chenyang Shi, Qingliang Zhao*, Naibo Lin*, Xiangyang Liu*. Biomimetic synthesis of 2D ultra-small copper sulfide nanoflakes based on reconfiguration of the keratin secondary structure for cancer theranostics in the NIR-II region. J Mater. Chem. B, 2022. (IF 6.331).

6.   Linhai Yang#, Yulun Chen#, Jing Wang, Shuting Ling, Guangxing Wang, Bei Zhang, Hengyu Zhao*, Qingliang Zhao*, Jingsong Mao*.  Research progress on the application of optical coherence tomography in the field of oncology. Front. Oncol. 2022, 953934. (IF 5.738).

7.   Yi Xue#, Wu Bao#, Jie Zhou, Qingliang Zhao, Su-Zhuang Hong, Jun Ren,Bai-Cheng Yang, Peng Wang, Bin Yin, Cheng-Chao Chu*, Gang Liu*and Chi-Yu Jia*. Global Burden, Incidence and Disability-Adjusted Life-Years for Dermatitis: A Systematic Analysis Combined With Socioeconomic Development Status, 19900-2019. Front. Cell. Infect. MI, 2022. (IF 6.073).

8.   Yang Zhao#, Ziyang Mei#, Xiaoxiao Luo, Jingsong Mao, Qingliang Zhao, Gang Liu, Dezhi Wu*. Remote vascular interventional surgery robotics: a literature review. Quant. Imaging Med. Surg, 2022. 1-792. (IF 4.63).

9.   Doudou Huang^#, Guangxing Wang^#, Jingsong Mao^#, Chunlei Liu^#, Zhongxiong Fan, Yunrui Zhang, Bei Zhang, Yang Zhao, Cuixia Dai, Yaqin He, Heng Ma,* Gang Liu, Xiaoyuan Chen, Qingliang Zhao*,  Intravital Whole-process Monitoring Thermo-Chemotherapy via 2D Silicon  Nanoplatform: A Macro Guidance and Long-term Microscopic Precise Imaging  Strategy, Adv. Sci., 2021, 202101242 (1-15) (Cover Picture).(IF 16.806).

10.   Zhaohua Miao^#, Doudou Huang^#,Yichuan Wang, Wei-Jian Li*, Linxin Fan,Jingguo Wang, Yan Ma, Qingliang Zhao*,  and Zhengbao Zha*, “Safe-by-Design Exfoliation of Niobium Diselenide  Atomic Crystals as A Theory-Oriented 2D Nanoagent from Anti-Inflammation  to Antitumor”, Adv Funct. Mater, 2020, 2001593 (1-13).(IF 18.808).

11.   Yali Huang^#, Minghui Li^#, Doudou Huang^#, Qi Qiu, Wenzhen Lin^@, Jiyan Liu^@, Wensheng Yang, Youliang Yao, Guoliang Yan, Ning Qu, Valery V. Tuchin, Shanhui Fan, Gang Liu, Qingliang Zhao*, Xiaoyuan Chen*. Depth-resolved enhanced spectral-domain OCT imaging of live mammalian embryos using gold nanoparticles as contrast agent. Small, 2019, 15(35):1902346.（IF 13.281）

12.   Doudou Huang^#, Yali Huang^#, Qi Qiu, Kai Wang^@, Zhihong Li^@, Youliang Yao, Gang Liu, Qingliang Zhao^*, Xiaoyuan Chen^*, Three-dimensional label-free imaging of mammalian yolk sac vascular remodeling with optical resolution photoacoustic microscopy. Photoacoustics. 2020, 17, 100152.（IF 5.577）

13.    Yu Chen#, Haitao Wu#, Hu Zhou#, Zhaohua Miao*, Fengqiu Hong, Qingliang Zhao, Zhenchao Tao, Yan Ma, Weidong Zhao*, and Zhengbao Zha*, PEGylated Indium Nanoparticles: A Metallic Contrast Agent for Multiwavelength Photoacoustic Imaging and Second Near-Infrared Photothermal Therapy. ACS Appl. Mater. Interfaces, 2021,13(39). (IF 9.229).

14.   Yifan Yang^#, Zhongxiong Fan^#, Kaili Zheng, Dao Shi, Guanghao Su, Qingliang Zhao*, Xu Fu*, Zhenqing Hou*, Self-recognizing theranostic nanoplatforms for photoacoustic imaging-monitored influence of ROS on SaO₂ signal of tumor microenvironment and enhanced chemo-sonodynamic therapy, J Mater. Chem. B, 2021, 9(27):5547-5559.（IF 6.331）

15.   Xiao Xu^#, Lin Che^#, Lin Xu, Doudou Huang, Jiashen Wu, Zebang Du, Yuchun Lin, Xiaoqian Hu, Qingliang Zhao*,  Zhongning Lin*and Ling Xu*, Green preparation of anti-inflammation an  injectable 3D porous hydrogel for speeding up deep second-degree scald  wound healing, RSC Adv, 2020, 10, 36101-36110.（IF 3.361）

16.   Kaihang Xue^#, Haina Tian, Fukai Zhu, Fanfan Wang, Zhongxiong Fan, Qingliang Zhao, Zhenqing Hou*,  Yang Li*, “Ultralong-Circulating and Self-Targeting “Watson-Crick  A=T”-Inspired Supramolecular Nanotheranostics for NIR-II Imaging-Guided  Photo-Chemotherapy”, ACS. Appl. Mater. Interfaces, 2020, 12, 29, 32477-32492.（IF 9.229）

17.   Heng Sun^#, Zhongxiong Fan^#, Sijin Xiang, Wenbao Zuo, Yifan Yang, Doudou Huang, Guanghao Su, Xu Fu*, Qingliang Zhao*,  Zhenqing Hou*, “A Novel Self-Distinguished Dual Stimulus-Responsive  Therapeutic Nanoplatform for Intracellular On-Demand Drug Release”, Mol Pharm. 2020, 17, 7, 2435-2450.（IF 4.939）

18.   Yi Xue#, Wu Bao# Jie Zhou, Qingliang Zhao, Su-Zhuang Hong, Jun Ren, Bai-Cheng Yang, Peng Wang, Bin Yin, Cheng-Chao Chu*, Gang Liu* and Chi-Yu Jia* Global Burden, Incidence and Disability-Adjusted Life-Years for Dermatitis: A Systematic Analysis Combined With SocioeconomicDevelopment Status, 1990–2019, Front Cell  Infect Mi, 2022, 12, 861053. (IF 5.293)

19.   Zhongxiong Fan^#, Beili Jiang^#, Qixin Zhu, Sijin Xiang, Li Tu, Yifan Yang, Qingliang Zhao, Doudou Huang, Jian Han, Guanghao Su, Dongtao Ge*, Zhenqing Hou*. Tumor-specific endogenous Fe^#-Activated,  MRI-Guided selfTargeting gadolinium-coordinated theranostic  nanoplatforms for amplification of ROS and enhanced chemodynamic-chemo  therapy. ACS Appl. Mater. Interfaces, 2020 ,12 (13)14884-14904.（IF=9.229）

20.   Lisi Xei^#, Xin Pang^#, Xiaohui Yan*, Qixuan Dai, Huirong Lin, Jing Ye, Yi Cheng, Qingliang Zhao, Xing Ma, Xianzhong Zhang, Gang Liu*, and  Xiaoyuan Chen*, Photoacoustic Imaging-Trackable Magnetic Microswimmers for Pathogenic Bacterial Infection Treatment. ACS Nano, 2020, 14, 3, 2880-2893.（IF=15.881）

21.   Chengchao Chu^*#, Jingwen Yu^#, En Ren#, Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li,* Zuguo Liu, Xiaoyuan Chen, and Gang Liu*. Multimodal photoacoustic imaging-guided regression of corneal neovascularization: A non-invasive and safe strategy. Adv. Sci, 2020, 2000346.（IF=16.806）

22.   Zhaohua Miao^#, Peiying Liu^#, Yichuan Wang, Kai Li, Doudou Huang, Huanjie Yang, Qingliang Zhao, Zhengbao Zha, Liang Zhen, and ChengYan Xu^*. PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors. Small. 2019, 15(41):1903596.（IF=13.281）

23.   Yuwei Qiu^#, Dandan Ding, Wenjing Sun, Yushuo Feng, Doudou Huang, Sicheng Li&, Shanshan Meng, Qingliang Zhao*, Li-Jun Xue*, Hongmin Chen*. Hollow mesoporous carbon nanospheres for imaging-guided light-activated synergistic thermo-chemotherapy. Nanoscale, 2019, 11(35):16351-16361.（IF=7.790）

24.   周康为，杨林海，邱棋，郑翔隆，蒋位财，林李嵩*，赵庆亮*. 光透明技术在骨透明化中的生物医学成像应用与展望[J].激光与光电子学进展, 2021, 58(20):200000.

25.   Zhaohua Miao^#, Sheng Chen^#, Cheng-Yan Xu, Yan Ma, Haisheng Qian ,Yunjun Xu, Huajian Chen, Xianwen Wang, Gang He, Yang Lu*, Qingliang Zhao and Zhengbao Zha*. PEGylated rhenium nanoclusters: a degradable metal photothermal nanoagent for cancer therapy. Chem. Sci, 2019, 10(21):5435-5443.（IF=9.825）

26.   Linxin Fan^#, Doudou Huang^#, Yichuan Wang, Zhaohua Miao, Yan Ma, Qingliang Zhao^*, Zhengbao Zha^*. Cryo-assisted exfoliation of atomically thin 2D Sb₂Se₃ nanosheets for photo-induced theranostics. Chem. Commun., 2019, 55(19): 2805-2808.（IF=6.222）

27.   黄豆豆^#，邱棋^#，林文珍，刘基嫣，黄雅丽，赵庆亮*，光声／超声双模态成像技术在生物医学中的新进展. 光散射学报, 2019, 31(1): 1-10.

28.   Qingliang Zhao^#,  Nian Liu, Menglin Song, Wenjing Sun, Xiaolian Sun*. Temperature  response mesoporous hollow carbon spheres with high loading and thermal  conversion efficiency for photoacoustic imaging and chemo/photothermal  tumor therapy in vivo. China Nanomedicine 2016/Nanomedicine: Nanotechnology, Biology, and Medicine, 2018, 14(5): 1860.（IF=6.458）

29.   Fei Ye^#, Meirong Li, Siqi Zhu, Qingliang Zhao^*, Jingang Zhong^*. Diagnosis of dermatophytosis using single fungus endogenous fluorescence spectrometry. Biomed. Opt. Express, 2018, 9(6): 2733-2742.（IF=3.732）

30.   Huirong Lin^#, Shuang Li, Junqing Wang, Chengchao Chu, Yang Zhang, Xin Pang, Peng Lv, Xiaoyong Wang, Qingliang Zhao, Junjie Chen, Hongmin Chen, Wen Liu, Xiaoyuan Chen and Gang Liu*. A single-step multi-level supramolecular system for cancer sonotheranostics. Nanoscale Horizons, 2019, 4(1):190-195.（IF=10.989）

31.   Zhaohua Miao^#, Lanxiang Lv, Kai Li, Peiying Liu, Zhenglin Li, Huanjie Yang*, Qingliang Zhao, Manli Chang, Liang Zhen, Cheng-Yan Xu*. Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy. Small. 2018, 14(14):1703789.（IF=13.281）

32.   Zhaohua Miao, Kai Li, Peiying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, ChengYan Xu. Natural Humic‐Acid‐Based Phototheranostic Agent. Adv. Healthcare Mater, 2018, 7(7):1701202.（IF=9.933）

33.    MeirongHou^#, Chenggong Yan, Zelong Chen, Qingliang Zhao, MiaomiaoYuan, YikaiXu, Bingxia Zhao. Multifunctional NIR-responsive poly (vinylpyrrolidone)-Cu-Sb-S nanotheranostic agent for photoacoustic imaging and photothermal/photodynamic therapy. Acta Biomaterialia, 2018, 74: 334-343.（IF=8.947）

34.   Jinyuan Ma, Hongjie Wu, Yang Li, Zehua Liu, Guihua Li, Yuxin Guo, Zhenqing Hou, Qingliang Zhao, Dengyue Chen*, and Xuan Zhu*. Novel Core-Interlayer-Shell DOX/ZnPc Co-loaded MSNs@ pH-Sensitive CaP@ PEGylated Liposome for Enhanced Synergetic Chemo-Photodynamic Therapy. Pharmaceutical Research, 2018, 35(3):57.（IF=4.200）

35.    Qingliang Zhao^#,  Cuixia Dai, Shanhui Fan, Jing Lv, Liming Nie*. Synergistic efficacy of  salicylic acid with a penetration enhancer on human skin monitored by  OCT and diffuse reflectance spectroscopy. Sci. Rep, 2016, 6:34954.（IF=4.379）

36.   Qingliang Zhao^#, Lin Li^#, Qian Li, Xia Jiang, Qiushi Ren, Xinyu Chai*, Chuanqing Zhou*.  Concentration dependence of optical clearing on the enhancement of  laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM)  imaging., J. Biomed. Opt, 2014, 19(3):36019.（IF=3.170）

37.   Jing Lv^#, Ya Peang, Shi Li, Zhide Guo, Qingliang Zhao, Z., Xiangzhong Zhang and Nie L.*. Hemispherical photoacoustic imaging of myocardial infarction: in vivo detection and monitoring. European Radiology, 2017, 28(5):2176-2183.（IF=5.315）

38.   Lin Li^#, Qian Li, Cuixia Dai, Qingliang Zhao, Tianhao Yu, Xinyu Chai*, Chuanqing Zhou*. Automated segmentation and quantitative study of retinal pigment epithelium cells for photoacoustic microscopy imaging. Chin. Opt. Lett, 2017, 15(5):051101.（IF=2.448）

39.   Yu. Liu^#, Ning. Kang^#, Zijian Zhou, Qingliang Zhao, L. Ma, Lei Ren*, Liming Nie*. Deep photoacoustic/optical/magnetic resonance multimodal imaging in living subjects using high-efficient upconversion nanocomposites. Adv. Mater, 2016, 28(30):6411-6419.（IF=30.849）

40.   Qian Li^#, Lin Li, Tianhao Yu, Qingliang Zhao, Chuanqing Zhou*, Xinyu Chai*. Vascular tree extraction for photoacoustic microscopy and imaging of cat primary visual cortex. J. Biophotonics, 2016, 10(6-7):780-791.（IF=3.207）

41.   Lin. Li^#, Cuixia. Dai^#, Qian. Li, Qingliang Zhao, Xinyu Chai*, Chuanqing Zhou*. Fast subcellular optical coherence photoacoustic microscopy for pigment cell imaging. Opt. Lett, 2015, 40(19):4448.（IF=3.776）

著作：

[1] Combination of tissue optical clearing and OCT for tumor diagnosis via permeability coeffcient measurements Dr. Qingliang Zhao. Handbook of Tissue Optical Clearing：New Prospects in Optical Imaging, edited by Dr. V. V. Tuchin, Dr. D. Zhu & Dr. E. A. Genna, 2022, ISBN: 978-0-367-89509-9.

[2] Applications of Optical Technology for Materials Monitoring in Wound Healing and Management Dr. Qingliang Zhao, MD. Lin Chen. Wound Healing - Recent Advances and Future Opportunities, edited by Dr. Ana Colette Mauricio, 2022, ISBN 978-1-80356-225-4.

专利成果

1．赵庆亮，刘刚，陈小元，王骁勇。双模态成像系统，授权号：ZL201720563551.8.

2．赵庆亮，刘刚，陈小元。“多光谱多光学技术融合的测温装置”， 授权号：ZL201721307191.1.

3．赵庆亮，黄豆豆，林文珍，刘基嫣。基于液体透镜自聚焦的双模态内窥镜装置，授权号：ZL201811547208.X.

4．赵庆亮，黄雅丽，刘刚，黄豆豆，张小芬，林文珍，刘基嫣，严文豪，龚向莲。一种早期胚胎光学相干层析图像对比的增强方法，授权号：ZL201910478806.4.

5．赵庆亮，张芸瑞，邱棋，杨林海。一种适用于光学相干成像的实验鼠脑部固定装置，授权号：ZL202022899611.8

6．刘刚， 代奇轩， 陈虎， 楚成超， 毛景松， 赵庆亮。一种改性聚桂醇泡沫硬化剂和制备方法及应用，中国，申请：202110256781.0.