教育背景
2010.9-2014.7 中国海洋大学 食品科学博士
2011.9-2013.9 美国圣路易斯华盛顿大学 联合培养
2007.9-2010.7 中国海洋大学 食品科学 硕士
2003.9-2007.7 中国海洋大学 生物科学 学士
工作经历
2019.6-至今 bet体育365官网正规 助理教授
2014.7-2019.5 上海海洋大学食品学院 讲师
主要研究领域
利用动物和细胞模型围绕代谢开展妊娠和代谢疾病的相关研究。
一方面,研究代谢如何维持正常妊娠以及代谢失调引发妊娠不良母胎结局的机制。另一方面,研究膳食因素与肥胖/糖尿病/非酒精脂肪肝的关系,同时关注致病成分(食品加工有害产物AGEs)和保护成分(食品功效成分、经典营养素)的作用。
代表性成果
主持/参与项目:
1. 晚期糖基化终末产物通过加速β细胞衰老导致胰岛功能衰退的机制研究, 厦门市自然科学基金,2023.7-2026.6,主持
2. 建立我国胎儿生长曲线和胎儿生长受限干预体系的全链条研究,国家重点研发计划,2022.12-2025.11,课题骨干
3. 胎盘发育障碍致子痫前期的机制及相关干预策略,国家重点研发计划,2018.12-2021.11,课题骨干
4. 胎盘维持母胎代谢互作稳态的细胞分子机制,国家自然科学基金重点项目,2022.1-2026.12,主要研究者
5. 膳食AGEs在脂肪组织内蓄积规律及其安全性评价,国家自然科学基金青年基金,2017.1-2019.12,主持
6. 褐藻多酚对脂肪炎症的改善作用和机制研究,上海市高校教师资助计划, 2015.1-2016.12,主持
7. 典型食品加工条件下特征动物生物活性物质多尺度结构变化与功能调控机制,国家重点研发计划, 2016.12-2020.12,主要研究者
近五年发表论文:
1. Yu Miao†, Hu Xiaoqian†, Pan, Zihang, Du Cui; Jiang Jing, Zheng Wanshan, Cai Han, Wang Yinan, Deng Wenbo, Wang Haibin, Lu Jinhua, Sun Ming-an*; Cao Bin*. Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization. Nucleic Acids Research. 2023, 51(10):4745-4759.
2.Wenzhe Yu†, Beiang Zhang†, Xiao Hong, Han Cai, Yinan Wang, Jinhua Lu, Xiaoqian Hu*, Bin Cao*. Identification of desoxyrhapontigenin as a novel antiviral agent against congenital Zika virus infection. Antiviral Research. 2023, 211:105542.
3. Lida Fan†,Wenzhe Yu†, Beiang Zhang, Bin Cao, Mingfu Wang*, Xiaoqian Hu*. Distinctive effects of different types of advanced glycation end-products (AGEs) on liver glucose metabolism. Food Funct. 2022, 13(21):11298-11306.
4. Wenzhe Yu, Lida Fan, Mingfu Wang, Bin Cao*, Xiaoqian Hu*. Pterostilbene improves insulin resistance caused by advanced glycation end products (AGEs) in hepatocytes and mice. Mol Nutr Food Res. 2021, 65(15):e2100321. (Cover story)
5. Wenzhe Yu, Xiaoqian Hu, Bin Cao*. Viral Infections During Pregnancy: The Big Challenge Threatening Maternal and Fetal Health. Matern Fetal Med. 2021, 4(1):72-86.
6. Xiaoqian Hu, Mingfu Wang*, Fereidoon Shahidi*. Antiglycative and anti-inflammatory effects of lipophilized tyrosol derivatives. Food Production Processing and Nutrition. 2020, 2(1):28.
7. Yueliang Zhao, Hongyun Kong, Xu Zhang, Xiaoqian Hu*, Mingfu Wang*. The effect of Perilla (Perilla frutescens) leaf extracts on the quality of surimi fish balls. Food Science and Nutrition, 2019, 7(6): 2083-2090.
8. Wenzhe Yu, Xiaoqian Hu*, Mingfu Wang*. Pterostilbene inhibited advanced glycation end products (AGEs)-induced oxidative stress and inflammation by regulation of RAGE/MAPK/NF-κB in RAW264.7 cells. Journal of functional foods, 2018, 40: 272-279.
9. Yueliang Zhao†, Xiaoqian Hu†, Xinyuan Zuo, Mingfu Wang*. Chemopreventive effects of some popular phytochemicals on human colon cancer: A review. Food Funct., 2018, 9, 4548.
10. Yun Yao, Kehai Liu, Yueliang Zhao, Xiaoqian Hu*, Mingfu Wang. Pterostilbene and 4’-Methoxyresveratrol inhibited lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. Molecules. 2018, 23(5), 1148.
11. Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu*, Mingfu Wang*. 4’-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-κB and NLRP3 Inflammasome Pathway. Molecules 2018, 23(6), 1447.
12. Jing Teng, Yunlong Li, Wenzhe Yu, Yueliang Zhao, Xiaoqian Hu, Ning-ping Tao, Mingfu Wang*. Naringenin, a common flavanone, inhibits the formation of AGEs in bread and attenuates AGEs-induced oxidative stress and inflammation in RAW264.7 cells. Food chemistry, 2018, 269:35-42.