袁伦志 助理教授
Email: yuanlunzhi@xmu.edu.cn
地址：厦门大学国家传染病诊断试剂与疫苗工程技术研究中心220室
个人简介
袁伦志博士于2019年在bet体育365官网正规获得生物化学与分子生物学博士学位（导师：夏宁邵教授）；2019年至2022年在厦门大学国家传染病诊断试剂与疫苗工程技术研究中心从事博士后研究工作；2022年入选厦门大学南强青年拔尖人才支持计划；主要从事基于复杂人源化动物模型和特殊动物模型的重大及新发突发感染性疾病预防及治疗机制创新研究；主持建立肝脏和免疫系统双嵌合小鼠模型，揭示HBV慢性感染导致炎症和肝脏纤维化的系列研究入选国家科技重大专项“十三五”优秀成果，获得学习强国、新华网等主流媒体评述；主持运用仓鼠、人肺移植小鼠、hACE2转基因小鼠、外植体等模型体系开展广谱免疫策略、多靶点治疗药物研发、重症肺炎和多器官衰竭调控机制等研究，相关成果获得科学网、病毒学界等媒体报道；曾获浙江省科技进步一等奖、厦门大学“萨本栋奖学金”等荣誉。
主要研究方向
1.肝、肺、免疫系统人源化动物模型在人类疾病研究中的应用
2.年龄、性别、基础疾病等宿主因素对病原体感染的影响
3.感染性疾病慢性化和后遗症的形成机制和病理学特征
4.多重病原体感染互作和宿主免疫应答规律
5.炎性组织损伤和多器官衰竭的靶向治疗策略
近五年代表性研究论文
1. Xia, L.#, Yuan, L.#, Hu, Y.#, Liu, J.#, Hu, G.#, Qi, R.#, Zhang, T., Xiong, H., Zheng, Z., Lin, H., Zhang, J., Yu, C., Zhou, M., Ma, J., Cheng, T., Chen, R., Guan, Y., Xia, N.*, Liu, W.*. A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19[J]. Cell Mol Immunol, 2023; https://doi.org/10.1038/s41423-023-00985-3.
2. Sun, S.#, Yang, H.#, Xin, J.#, Yao, H.#, Yuan, L.#, Ren K., Jiang J., Shi D., Li J., Zhou Q., An Z., Guo B., Chen J., He L., Liang X., Cheng T.*, Xia N.*, Li J.*. Transcriptomics confirm the establishment of a liver-immune dual-humanized mouse model after transplantation of a single type of human BMSC[J]. Liver International. 2023; https://doi.org/10.1111/liv.15546.
3. Ma, J.#, Liu, X.#, Zhou, M #, Chen, P.#, Chen, R., Wang, J., Zhu, H., Wu, K., Ye, J., Zhang, Y., Yuan, Q., Tang, Q.*, Yuan, L.*, Cheng, T.*, Guan, Y., Xia, N. A Heterologous Challenge Rescues the Attenuated Immunogenicity of SARS-CoV-2 Omicron BA.1 Variant in Syrian Hamster Model[J]. J Virol. 2023; 97(2):e0168422. doi: 10.1128/jvi.01684-22.
4. 袁伦志，张天英，张军，夏宁邵. 面向新冠肺炎疫情防控需求的应用基础研究.《中国科学基金》，2022，36（4）：614-623.
5. Yuan, L.#, Zhu, H.#, Chen, P.#, Zhou, M., Ma, J., Liu, X., Wu, K., Chen, R., Liu, Q., Yu, H., Li, L., Wang, J., Zhang, Y., Ge, S., Yuan, Q., Tang, Q., Cheng, T.*, Guan, Y.*, Xia, N.*. Infection, pathology and interferon treatment of the SARS-CoV-2 Omicron BA.1 variant in juvenile, adult and aged Syrian hamsters[J]. Cell Mol Immunol, 2022, 19(12): 1392-1399.
6. Yuan, L.#, Zhu, H.#, Zhou, M.#, Ma, J.#, Liu, X., Wu, K., Ye, J., Yu, H., Chen, P., Chen, R., Wang, J., Zhang, Y., Ge, S., Yuan, Q., Cheng, T.*, Guan, Y.*, Xia, N.*. Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model[J]. iScience, 2022, 25(12): 105475.
7. Yuan, L.#, Zhou, M.#, Ma, J.#, Liu, X., Chen, P., Zhu, H., Tang, Q., Cheng, T.*, Guan, Y.*, Xia, N.*. Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters[J]. Cell Mol Immunol, 2022, 19(2): 290-292.
8. Yuan, L.#, Zhu, H.#, Zhou, M.#, Ma, J.#, Chen, R.#, Yu, L., Chen, W., Hong, W., Wang, J., Chen, Y., Wu, K., Hou, W., Zhang, Y., Ge, S., Chen, Y., Yuan, Q., Tang, Q.*, Cheng, T.*, Guan, Y.*, Xia, N.*. Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19[J]. Protein Cell, 2022, 13(1): 72-77.
9. Yuan, L.#, Zhu, H.#, Wu, K.#, Zhou, M., Ma, J., Chen, R., Tang, Q., Cheng, T.*, Guan, Y.*, Xia, N.*. Female sex hormone, progesterone, ameliorates the severity of SARS-CoV-2-caused pneumonia in the Syrian hamster model[J]. Signal Transduct Target Ther, 2022, 7(1): 47.
10. Yuan, L.#, Zhu, H.#, Zhou, M.#, Ma, J.#, Chen, R.#, Chen, Y., Chen, L., Wu, K., Cai, M., Hong, J., Li, L., Liu, C., Yu, H., Zhang, Y., Wang, J., Zhang, T., Ge, S., Zhang, J., Yuan, Q., Chen, Y., Tang, Q., Chen, H., Cheng, T.*, Guan, Y.*, Xia, N.*. Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster[J]. Signal Transduct Target Ther, 2021, 6(1): 136.
11. Yuan, L.#, Tang, Q.#, Zhu, H., Guan, Y., Cheng, T.*, Xia, N.*. SARS-CoV-2 infection and disease outcomes in non-human primate models: advances and implications[J]. Emerg Microbes Infect, 2021, 10(1): 1881-1889.
12. Yuan, L.#, Tang, Q.#, Cheng, T.*, Xia, N.*. Animal models for emerging coronavirus: progress and new insights[J]. Emerg Microbes Infect, 2020, 9(1): 949-961.
13.Yuan, L.#, Jiang, J.#, Liu, X.#, Zhang, Y., Zhang, L., Xin, J., Wu, K., Li, X., Cao, J., Guo, X., Shi, D., Li, J., Jiang, L., Sun, S., Wang, T., Hou, W., Zhang, T., Zhu, H., Zhang, J., Yuan, Q., Cheng, T.*, Li, J.*, Xia, N.*. HBV infection-induced liver cirrhosis development in dual-humanised mice with human bone mesenchymal stem cell transplantation[J].Gut, 2019, 68(11): 2044-2056. 入选国家科技重大专项“十三五”优秀成果
14. Yuan, L.#, Zhang, Y.#, Liu, X.#, Chen, Y., Zhang, L., Cao, J., Li, X., Wang, M., Wu, K., Zhang, J., Liu, G., Tang, Q., Yuan, Q.*, Cheng, T.*, Xia, N.*. Agonist c-Met monoclonal antibody augments the proliferation of hiPSC-derived hepatocyte-like cells and improves cell transplantation therapy for liver failure in mice[J]. Theranostics, 2019, 9(7): 2115-2128.
15. Yuan, L.#, Liu, X.#, Zhang, L.#, Zhang, Y., Chen, Y., Li, X., Wu, K., Cao, J., Hou, W., Que, Y., Zhang, J., Zhu, H., Yuan, Q., Tang, Q.*, Cheng, T.*, Xia, N.*.Optimized HepaRG is a suitable cell source to generate the human liver chimeric mouse model for the chronic hepatitis B virus infection[J]. Emerg Microbes Infect, 2018, 7(1): 144.
16. Yuan, L.#, Liu, X.#, Zhang, L.#, Li, X., Zhang, Y., Wu, K., Chen, Y., Cao, J., Hou, W., Zhang, J., Zhu, H., Yuan, Q., Tang, Q.*, Cheng, T.*, Xia, N.*. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection[J]. Front Microbiol, 2018, 9: 908.
17. Chen, J.#, Wang, P.#, Yuan, L.#, Zhang, L.#, Zhang, L.#, Zhao, H.#, Chen, C.#, Wang, X.#, Han, J.#, Chen, Y.#, Jia, J., Lu, Z., Hong, J., Lu, Z., Wang, Q., Chen, R., Qi, R., Ma, J., Zhou, M., Yu, H., Zhuang, C., Liu, X., Han, Q., Wang, G., Su, Y., Yuan, Q., Cheng, T., Wu, T., Ye, X., Zhang, T.*, Li, C.*, Zhang, J.*, Zhu, H.*, Chen, Y.*, Chen, H.*, Xia, N.*. A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2[J]. Sci Bull, 2022, 67 (13) ,1372-1387.
18. Wang, S.#, Sun, H.#, Zhang, Y.#, Yuan, L.#, Wang, Y.#, Zhang, T.#, Wang, S., Zhang, J., Yu, H., Xiong, H., Tang, Z., Liu, L., Huang, Y., Chen, X., Li, T., Ying, D., Liu, C., Chen, Z., Yuan, Q., Zhang, J.*, Cheng, T.*, Li, S.*, Guan, Y.*, Zheng, Q.*, Zheng, Z.*, Xia, N.*. Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron[J]. Cell Rep, 2022, 39(8): 110862.
19. Wu, Y.#, Wang, S.#, Zhang, Y.#, Yuan, L.#, Zheng, Q.#, Wei, M.#, Shi, Y.#, Wang, Z., Ma, J., Wang, K., Nie, M., Xiao, J., Huang, Z., Chen, P., Guo, H., Lan, M., Xu, J., Hou, W., Hong, Y., Chen, D., Sun, H., Xiong, H., Zhou, M., Liu, C., Guo, W., Guo, H., Gao, J., Gan, C., Li, Z., Zhang, H., Wang, X., Li, S., Cheng, T., Zhao, Q., Chen, Y., Wu, T., Zhang, T.*, Zhang, J.*, Cao, H.*, Zhu, H.*, Yuan, Q.*, Guan, Y.*, Xia, N.*. Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine[J]. Cell Host Microbe, 2022, 30(12): 1732-1744 e7.
20. Xiong, H.#, Sun, H.#, Wang, S.#, Yuan, L.#, Liu, L.#, Zhu, Y.#, Zhang, J.#, Huang, Y., Qi, R., Jiang, Y., Ma, J., Zhou, M., Ma, Y., Fu, R., Yan, S., Yue, M., Wu, Y., Wei, M., Wang, Y., Li, T., Wang, Y., Zheng, Z., Yu, H., Cheng, T., Li, S.*, Yuan, Q.*, Zhang, J.*, Guan, Y.*, Zheng, Q.*, Zhang, T.*, Xia, N.*. The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2[J]. Proc Natl Acad Sci U S A, 2022, 119(34): e2204256119.
21. Wu, Y.#, Huang, X.#, Yuan, L.#, Wang, S.#, Zhang, Y.#, Xiong, H.#, Chen, R., Ma, J., Qi, R., Nie, M., Xu, J., Zhang, Z., Chen, L., Wei, M., Zhou, M., Cai, M., Shi, Y., Zhang, L., Yu, H., Hong, J., Wang, Z., Hong, Y., Yue, M., Li, Z., Chen, D., Zheng, Q., Li, S., Chen, Y., Cheng, T., Zhang, J.*, Zhang, T.*, Zhu, H.*, Zhao, Q.*, Yuan, Q.*, Guan, Y.*, Xia, N.*. A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters[J]. Sci Transl Med, 2021.
22. Zhang, Y.#, Wang, S.#, Wu, Y., Hou, W.#, Yuan, L.#, Shen, C.#, Wang, J., Ye, J., Zheng, Q., Ma, J., Xu, J., Wei, M., Li, Z., Nian, S., Xiong, H., Zhang, L., Shi, Y., Fu, B., Cao, J., Yang, C., Li, Z., Yang, T., Liu, L., Yu, H., Hu, J., Ge, S., Chen, Y., Zhang, T., Zhang, J., Cheng, T.*, Yuan, Q.*, Xia, N.*. Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors[J]. Small Methods, 2021, 5(2): 2001031.
23. Fu, W.#, Wang, W.#, Yuan, L.#, Lin, Y., Huang, X., Chen, R., Cai, M., Liu, C., Chen, L., Zhou, M., Wu, K., Zhao, H., Pan, D., Ma, J., Hong, J., Zhai, B., Zhang, Y., Kong, Z., Wang, Y., Chen, Y., Yuan, Q., Zhu, H.*, Cheng, T.*, Guan, Y.*, Xia, N.*. A SCID mouse-human lung xenograft model of SARS-CoV-2 infection[J]. Theranostics, 2021, 11(13): 6607-6615.
24. Liu, X.#, Yuan, L.#, Zhang, L., Mu, Y., Li, X., Liu, C., Lv, P., Zhang, Y., Cheng, T., Yuan, Q.*, Xia, N., Chen, X., Liu, G.*. Bioinspired Artificial Nanodecoys for Hepatitis B Virus[J]. Angew Chem Int Ed Engl, 2018, 57(38): 12499-12503.
25. Sun, S.#, Yuan, L.#, An, Z., Shi, D., Xin, J., Jiang, J., Ren, K., Chen, J., Guo, B., Zhou, X., Zhou, Q., Jin, X., Ruan, S., Cheng, T., Xia, N. *, Li, J. * DLL4 restores damaged liver by enhancing hBMSC differentiation into cholangiocytes[J]. Stem Cell Res, 2020, 47: 101900.
主持或参加科研项目：
1. 国家自然科学基金委-青年项目，82002139，HBV治疗性抗体和宿主免疫系统TLR7信号通路协同作用的新型抗病毒机制初步研究，在研，主持
2. 中国博士后科学基金特别资助（站中），2020T130362，结题，主持
3. 中国博士后科学基金面上资助，2020M682092，结题，主持
4. 国家自然科学基金委员会，重点支持项目，U1905205，乙肝病毒核心抗体水平作为疾病转归预测新靶标的病毒宿主互作机制与临床转化研究，在研，参加
5. 国家自然科学基金委员会, 联合基金项目, U22A20333, 乙型肝炎相关性肝癌演进关键分子HBx的可视化诊疗策略，在研, 参加
6. 厦门市科技局，3502Z20221040，生物安全三级实验室功能提升科技创新平台项目，在研，课题骨干
7. 福建省科技厅-福建省科技创新平台建设计划项目，2022Y2001，生物安全三级实验室配套系统科技创新平台建设，在研，课题骨干
8. 国家科技重大专项办公室，新药创制重大专项，2018ZX09711003-005，DNA 病毒等重要或新发非烈性病毒药效学研究，结题，参加
9. 国家科技重大专项办公室，传染病防治重大专项，2017ZX10304402-002，人鼠嵌合与树鼩肝嵌合小鼠感染模型及应用研究，结题，课题骨干
其他学术活动：
American Society of Microbiology, ASM美国微生物协会会员
《Zoonoses》青年编委
《解放军医学杂志》青年编委
《Emerging Microbes & Infections》审稿人
《Journal of Virology》审稿人
《PLOS Pathogens》审稿人
《Frontiers in Genetics》审稿人
